Apitherapy, especially Bee Venom Therapy (BVT), uses the active ingredients in bee venom (apitoxin) to help control inflammation, immune responses, and brain chemistry. With documented use in traditional Chinese, European, and Egyptian medicine, BVT has experienced a resurgence recently thanks to studies that support its efficacy in rheumatoid arthritis, chronic pain, multiple sclerosis, and other autoimmune or neurodegenerative conditions.
Melittin: This peptide constitutes approximately 50% of the venom and has anti-inflammatory properties. It has been observed that it can inhibit the activity of pro-inflammatory enzymes and modulate the immune response.
Apamin: A neurotoxin that blocks potassium channels in the central nervous system, which can influence neuronal transmission and the excitability of neurons.
Hyaluronidase: An enzyme that facilitates the spread of venom in tissues and may contribute to cell regeneration.
These components, among others, interact with the immune and nervous systems, which could explain the effects observed in various health conditions.
History and cultural context
Bee venom has been used since ancient times, but it was only in recent decades that clinical trials began to be conducted to harness its full potential.
Ancient Egypt: records of the use of poison to treat arthritis and abscesses.
Classical Greece: Hippocrates described the application of bee stings for joint pain.
Medieval Europe: monks and apothecaries used "bee therapy" in creams and ointments.
Traditional Chinese Medicine: "Hot toxin" is used to balance qi and eliminate stasis.
Stimulates regulatory T cells (Treg) and normalizes the Th17/Treg ratio.
Conditions that potentially benefit from BVT
BVT has been explored as a complementary therapy in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Preliminary studies suggest that bee venom may modulate the immune response, reduce the production of pro-inflammatory cytokines and increase the activity of regulatory cells.
In cases of chronic lower back pain, acupuncture with bee venom has shown effectiveness in reducing pain and improving functionality. The analgesic effects are attributed to the inhibition of pain mediators and the modulation of neuronal signaling.
The anti-inflammatory capacity of bee venom has been investigated in diseases such as osteoarthritis and multiple sclerosis. Melittin can inhibit the activity of inflammatory enzymes, while apamin can affect neuronal excitability, contributing to the reduction of inflammation and pain.
Apamin, by blocking potassium channels in the central nervous system, can influence neurological disorders such as multiple sclerosis and Parkinson's disease. Although the studies are preliminary, its potential to improve neurological function and reduce associated symptoms is being investigated.
According to several medical studies, melittin has shown encouraging results in reducing antimicrobial activity against Borrelia burgdorferi, the bacteria that causes Lyme disease. In vitro studies suggest that bee venom may reduce the growth factor of these bacteria, although more clinical studies are needed to confirm its efficacy in humans.
At Mitogenesis, we prioritize the safety and well-being of our patients, ensuring that any complementary therapy is administered responsibly and based on evidence.
Bee venom therapy is a powerful tool within integrative medicine, requiring rigorous protocols and personalization. Its anti-inflammatory, analgesic, and neuromodulatory effects make it valuable in arthritis, neurodegenerative diseases, and chronic inflammatory conditions.
At Mitogenesis, we offer BVT as a complementary therapeutic option for selected patients. Our medical team carefully evaluates each case, considering the medical history, individual needs, and the potential benefits and risks of the therapy. We conduct the administration in a controlled environment, utilizing trained personnel and established safety protocols.
If you are considering integrative therapeutic options and want to know if BVT is suitable for you, we invite you to schedule a consultation with our team at Mitogenesis. We are committed to your health and well-being, offering personalized and evidence-based treatments.
Contact us at 480-781-4800, by email at info@mitogenesis.health, and visit our website for more information: www.mitogenesis.health.
Bee and Wasp Venoms (https://www.science.org/doi/10.1126/science.177.4046.314)
Therapeutic Use of Bee Venom and Potential Applications in Veterinary Medicine (https://pmc.ncbi.nlm.nih.gov/articles/PMC9965945/)
Bee Venom - Uses, Side Effects, and More (https://www.webmd.com/vitamins/ai/ingredientmono-972/bee-venom)
Therapeutic Potential and Mechanisms of Bee Venom Therapy: A Comprehensive Review of Apitoxin Applications and Safety Enhancement Strategies (https://www.mdpi.com/1424-8247/17/9/1211)
Reviewed by:
Dr. Mel Schottenstein
Naturopathic Doctor
NMD, MBE, MScN, FICT, FSCT
Disclaimer: The information in this article is provided for informational purposes only and is not a substitute for the advice of your physician or other health care professionals. Do not use the information to diagnose or treat a health problem or disease. Always consult with a healthcare professional before taking any medication or nutritional, herbal, or homeopathic supplement, or using any treatment for a health problem.
